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Definition of Lichenification Lichenification: Thick, leathery skin, usually the result of constant scratching and rubbing. With prolonged rubbing or scratching, the outer layer of the skin the epidermis becomes hypertrophied overgrown and this results in thickening of the skin and exaggeration of the normal skin markings, giving the skin a leathery bark-like appearance. Lichenification is a common consequence of atopic dermatitis eczema and other pruritic itchy disorders. It may also arise on seemingly normal skin.

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