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Definition of Dermatofibroma Dermatofibroma: A common type of benign skin tumor that is small, slow-growing, typically firm, red-to-brown and most often on the legs. Also called a fibrous histiocytoma. They can grow up to about 1 cm less than a half inch in diameter. A dermatofibroma consists of a proliferation of scar-like tissue within the deeper layers of the skin dermis. The cause of dermatofibromas is unknown. They are usually single but sometimes may be multiple. Simple excision is curative.

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