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Definition of Adducted thumbs with mental retardation Adducted thumbs with mental retardation: A syndrome with the following characteristic features: neurologically: mental retardation and aphasia lack of speech limbs: adducted clasped thumbs, absent extensor pollicis longus and/or brevis muscles to the thumb, shuffling gait, and leg spasticity growth: small body size skeleton: lumbar lordosis sway back The syndrome is inherited as an X-linked trait and so affects mainly boys. Alternative names include MASA syndrome MASA stands for mental retardation, aphasia, shuffling gait, and adducted thumbs, clasped thumb and mental retardation, congenital clasped thumb with mental retardation, and the Gareis-Mason syndrome.

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